If I have a home business or generate self-employment income, will I undoubtedly have to pay taxes at the end of the year?

Self-employment income generated through the year will definitely have tax implications for you come tax time. There are so many individual variables when determining what is owed in personal/business taxes, it is impossible to make a blanket statement. For a self-employed individual, most of the time you will be required to pay both your regular income tax and your self-employment tax. Tax deductions can lessen the end-of-the-year tax burden.
Putting away money throughout the year will help with any tax burden due at the end of the year.